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目的:探讨六亚甲基二乙酰胺(HMBA)联合辐射对人粘液表皮样癌MEC-1细胞超微结构的作用特点。方法:实验分4组,对照组细胞未经药物及射线处理;HMBA组细胞经1mmol/L的HMBA诱导作用96h;γ-射线组细胞在乏氧状态下接受7Gy的60Coγ-射线照射;联合应用组细胞按上述方法先经HMBA处理再接受辐射,用扫描电镜和透射电镜观察各组细胞的形态变化。结果:HMBA组细胞表面微绒毛减少,胞浆线粒体增多;γ-射线组细胞微绒毛凝聚,线粒体肿胀、空化;联合应用组细胞损伤明显,微绒毛凝聚、崩解,线粒体粘连、缺嵴、空化和紊乱。结论:HMBA能增强γ-射线对MEC-1细胞超微结构的破坏作用。
Objective: To investigate the effect of HMBA combined with radiation on the ultrastructure of human mucoepidermoid carcinoma cell line MEC-1. Methods: The experiment was divided into 4 groups, the control group of cells without drug and radiation treatment; HMBA group of cells by 1mmol / L of HMBA induced 96h; γ-ray group of cells under hypoxia 7Gy 60Coγ-ray irradiation; combined application Group cells were treated with HMBA as above and then irradiated. The morphological changes of the cells were observed by scanning electron microscopy and transmission electron microscopy. Results: The microvilli and cytoplasmic mitochondria increased on the surface of HMBA group. Microvilli coalescence and mitochondria swelling and cavitation occurred in γ-ray group. The cells in combination group had obvious cell damage, aggregation and disintegration of microvilli, mitochondria adhesion, Cavitation and disorders. Conclusion: HMBA can enhance the damaging effect of γ-rays on the ultrastructure of MEC-1 cells.