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根据一项调查显示,美国1991年抗药结核病乃至抗多种药物的结核病(MDR-TB)发生率很高(占总病例的3.5％)。HIV阴性和HIV阳性者的MDR-TB均难以治愈。在医院暴发MDR-TB的250多例AIDS中,死亡率超过80％。一些被抗7种药物的菌株感染者接受了包括异烟肼、利福平、吡嗪酰胺、环丝氨酸、链霉素和氧氟沙星等药的初治方案后,存活1年以上。虽然这一结果尚属满意,但需要考虑这种治疗成功的公卫后果。 1991年11月,1例39岁妇女被诊为AIDS。其CD_4细胞计数为40/μl,同时患有抗7种药物的结核病。经过积极治疗,到1992年4月,临床有效。体重增加,烧退,胸片上的异常消失,痰涂片也转阴。遂转入长期保健机构,但培养发现抗7种药物的菌株生长,于是再次入院。到1992年11月,虽然临床稳定,但一直留院观
According to a survey, the incidence of drug-resistant tuberculosis and even multi-drug resistant tuberculosis (MDR-TB) in the United States in 1991 was very high (3.5% of the total cases). MDR-TB in both HIV-negative and HIV-positive individuals is difficult to cure. In more than 250 AIDS cases in hospitals where MDR-TB has been reported, the mortality rate is over 80%. Some patients infected with strains of anti-7 drugs survived for more than 1 year after receiving a naive regimen including isoniazid, rifampicin, pyrazinamide, cycloserine, streptomycin and ofloxacin. Although this result is still satisfactory, it is necessary to consider the success of this treatment of public health consequences. In November 1991, a 39-year-old woman was diagnosed with AIDS. Its CD 4 cell count was 40 / μl, with tuberculosis resistant to 7 drugs at the same time. After active treatment, to April 1992, clinically effective. Weight gain, fever, abnormal chest X-ray disappeared, sputum smear also turn negative. Then transferred to long-term health care institutions, but found anti-7 strains of cultured strains growth, so again hospitalized. To November 1992, although clinically stable, but has been hospitalized