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目的:探讨普萘洛尔和硝苯地平对男性高血压患者性功能的影响。方法:选取2008年1月-2011年1月在延安大学附属医院就诊的94例高血压患者作为研究对象,将所有对象随机分为2组,一组采用普萘洛尔治疗,一组采用硝苯地平治疗,观察治疗8周前后血压及性功能的改变。结果:2组患者在药物治疗8周后,血压水平较治疗前均明显降低(P<0.05);采用普萘洛尔治疗前后,患者性功能明显降低(P<0.05),而采用硝苯地平治疗前后,患者性功能无明显变化;普萘洛尔组在治疗后勃起功能障碍发生率明显高于硝苯地平组;普萘洛尔组在治疗后,机体内睾酮含量明显降低(P<0.05),而硝苯地平在治疗后无明显改变(P>0.05)。结论:普萘洛尔能影响患者的性功能,而硝苯地平不影响患者的性功能,因此对于高血压患者在采用降压治疗时,选择硝苯地平较好。
Objective: To investigate the effect of propranolol and nifedipine on the sexual function of male patients with hypertension. Methods: A total of 94 hypertensive patients treated at Yan’an University Hospital from January 2008 to January 2011 were enrolled. All subjects were randomly divided into two groups. One group was treated with propranolol and the other group was treated with nitrendipine Phenyldipine treatment, observe the treatment of blood pressure and sexual function changes before and after 8 weeks. Results: After 8 weeks of treatment, blood pressure was significantly lower in both groups than before treatment (P <0.05). Before and after propranolol treatment, the patients’ sexual function decreased significantly (P <0.05), while nifedipine Before and after treatment, there was no significant change in sexual function; the incidence of erectile dysfunction in propranolol group was significantly higher than that in nifedipine group; the propranolol group was significantly decreased after treatment (P <0.05 ), While nifedipine did not change significantly after treatment (P> 0.05). CONCLUSIONS: Propranolol can affect the patient’s sexual function, while nifedipine does not affect the patient’s sexual function, so nifedipine is better for patients with hypertension when using antihypertensive therapy.