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本文报道了异胆汁酸的分离测定方法及在促发结肠癌上的作用并对比了膳食习惯及结肠癌发病率都不同的美国人及日本人粪便中甾醇及胆汁酸的含量,并进行了分析与讨论。甾醇在肝细胞内转变为初级胆汁酸即鹅脱氧胆酸(3α,7α,-二羟基-5β-烷酸)及胆酸(3α,7α,12α-三羟基-5β-胆烷酸),到肠道后在细菌7α-脱氢酶的作用下继而代谢为次级胆汁酸即石胆酸(3α-羟基-5β-胆烷酸)及脱氧胆酸(3α,12-α二羟基-5β-胆烷酸)。已报道这两种初级胆汁酸都有促发结肠癌的作
This paper reports the isolation and determination of iso-bile acids and its role in promoting colon cancer. The contents of sterols and bile acids in feces of Americans and Japanese people who have different dietary habits and colon cancer incidences are compared and analyzed Discuss with. Sterols are converted within hepatocytes into primary bile acids, chenodeoxycholic acid (3α, 7α, -dihydroxy-5β-alkanoic acid) and cholic acid (3α, 7α, 12α-trihydroxy-5β- After intestinal bacteria in the role of 7α-dehydrogenase and then metabolized into secondary bile acids that lithocholic acid (3α-hydroxy-5β-cholanic acid) and deoxycholic acid (3α, 12-α dihydroxy-5β- Cholic acid). Both primary bile acids have been reported to trigger colon cancer