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目的:比较氨氯地平、比索洛尔对高血压合并心绞痛患者中心动脉压(central artery pressure,CAP)及颈动脉内中膜厚度(intima-media thickness,IMT)的影响。方法:选择我院2013年8月-2014年9月收治的高血压合并心绞痛患者76例,随机分为观察组和对照组,各38例。观察组给予氨氯地平5 mg/d,对照组给予比索洛尔2.5 mg/d,疗程均为1年。测定并对比两组治疗前后血压、CAP、IMT变化情况以及心绞痛的治疗效果。结果:观察组治疗后CAP收缩压、舒张压、IMT分别为(130.36±5.09)mm Hg、(73.38±5.76)mm Hg、(0.89±0.08)mm,均明显低于对照组的(144.82±6.54)mm Hg、(84.89±6.14)mm Hg、(1.01±0.12)mm,差异均有统计学意义(P<0.05)。观察组治疗总有效率为89.47%,高于对照组的76.32%,但差异无统计学意义(P>0.05)。结论:氨氯地平与比索洛尔治疗高血压合并心绞痛的临床疗效相当,但氨氯地平在降低高血压合并心绞痛患者CAP、IMT方面的效果优于比索洛尔。
Objective: To compare the effects of amlodipine and bisoprolol on central artery pressure (CAP) and carotid artery intima-media thickness (IMT) in patients with hypertension and angina pectoris. Methods: A total of 76 patients with hypertension and angina pectoris admitted in our hospital from August 2013 to September 2014 were randomly divided into observation group and control group, with 38 cases in each group. The observation group was treated with amlodipine 5 mg / d, while the control group was given bisoprolol 2.5 mg / d for 1 year. The blood pressure, CAP, IMT changes and angina pectoris before and after treatment were measured and compared. Results: The systolic blood pressure, diastolic blood pressure and IMT in the observation group after treatment were (130.36 ± 5.09) mm Hg, (73.38 ± 5.76) mm Hg and (0.89 ± 0.08) mm, respectively, which were significantly lower than those in the control group (144.82 ± 6.54 ) mm Hg, (84.89 ± 6.14) mm Hg and (1.01 ± 0.12) mm, respectively, with statistical significance (P <0.05). The total effective rate of observation group was 89.47%, higher than 76.32% of control group, but the difference was not statistically significant (P> 0.05). CONCLUSION: Amlodipine and bisoprolol are comparable in the treatment of hypertension with angina pectoris. Amlodipine is superior to bisoprolol in reducing CAP and IMT in patients with hypertension and angina pectoris.