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目的探讨用荧光原位杂交分析的方法来检测少、弱、畸形精子症患者中精子XY染色体畸变率。方法将30例少、弱、畸形精子症患者和20例正常生育男性精液精子标本用荧光原位杂交分析的方法检测精子X和Y染色体的数目畸变的发生率,并将结果进行分析、比较。结果研究组单倍体精子数32 189个,其中单倍体X精子数占(45.34±6.56)%,单倍体Y精子数占(47.32±7.18)%;二倍体精子率为(0.168±0.059)%,精子X和Y染色体数目畸变率为7.34%。对照组单倍体精子数为19 246个,其中单倍体X精子数为(46.87±5.54)%,单倍体Y精子数为(49.32±6.17)%;二倍体精子率为(0.074±0.038)%,精子X和Y染色体数目畸变率为3.81%。两组二倍体精子率、精子数目畸变率差异有统计学意义(P<0.05)。结论少、弱、畸形精子症患者中精子X和Y染色体数目畸变率比正常生育人群高。
Objective To investigate the detection rate of XY chromosome aberration in patients with small, weak and abnormal sperm by fluorescence in situ hybridization (FISH). Methods Thirty cases of oligoasthenospermia and 20 cases of normal spermatozoa were detected by fluorescence in situ hybridization (FISH). The incidences of X and Y chromosome aberrations were detected and compared. Results The number of haploid spermatozoa was 32 189 in the study group, in which the number of haploid X sperm accounted for (45.34 ± 6.56)%, the number of haploid Y sperm accounted for (47.32 ± 7.18)%, the diploid sperm rate was (0.168 ± 0.059)%, the number of chromosome X and Y chromosome aberration rate was 7.34%. The number of haploid sperm was 19 246 in the control group, in which the number of haploid X sperm was (46.87 ± 5.54)%, the number of haploid Y sperm was (49.32 ± 6.17)%, the diploid sperm rate was (0.074 ± 0.038)%, the number of chromosome X and Y chromosome aberration rate of 3.81%. The diploid sperm rate and the sperm number aberration rate of the two groups had significant difference (P <0.05). Conclusions The frequency of X and Y chromosome aberrations in patients with less, weak and abnormal spermatozoa is higher than that of normal births.