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1939年,A.E.Oxfoxd从P.griseofuluum的培养液中分离出灰黄霉素(griseofluvin).1947年J.F.Grove等从P.janczewskii的培养物中分离出所谓的卷曲因子(curlling factor),后经鉴定与灰黄霉素是同一物质.这个抗生素当时作为农用抗生素被开发,后来发现经口服对人的表皮真菌病有治疗效果而受到重视,直到现在该抗生素还在临床上应用.1950年E.L.Hazen等发现制霉菌素(Nystatin).1955年W.Gold等发现两性霉素B(Amphotericin B).从此确立了真菌病的化学治疗.
AEOxfoxd isolated griseofluvin from the culture of P. griseofuluum in 1939. The so-called curling factor was isolated from the culture of P. Janczewskii by JF Grove et al. In 1947 and later identified Was the same substance as griseofulvin, which was then developed as an agricultural antibiotic and was later spotlighted for its therapeutic efficacy by oral administration on human epidermal mycosis, until now the antibiotic is still clinically applied. ELHazen et al. Nystatin was found, and in 1955 W. Gold et al. Found Amphotericin B, which established the chemotherapy for mycosis.