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目的探讨氯乙烯接触对工人体内的氧化损伤和肝损伤指标的影响,筛选氯乙烯接触可能的效应生物标志物。方法以160名氯乙烯接触工人为接触组,160名不接触氯乙烯的工人为对照组,测定血清中超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量,以及谷胱甘肽硫转移酶(GST)和乙醇脱氢酶(ADH)活力。结果氯乙烯接触均未对SOD活力、MDA含量和GST活力产生明显影响,氯乙烯接触工人血清ADH活力显著性高于对照组(P<0.01)。30 000mg～组GST和ADH活力明显高于对照组(P<0.05)。GST和ADH活力与累积接触剂量存在明显的剂量-反应关系。结论目前氯乙烯接触浓度下氯乙烯对机体的氧化损伤作用不显著。GST和ADH可能是氯乙烯接触的效应生物标志物,但是仍需进一步确认和探讨。
Objective To investigate the effects of exposure to vinyl chloride on oxidative damage and hepatic injury in workers and to screen possible biomarkers of exposure to vinyl chloride. Methods 160 workers exposed to vinyl chloride and 160 workers exposed to vinyl chloride were used as the control group. The levels of serum superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione Transferase (GST) and alcohol dehydrogenase (ADH) activity. Results There was no significant effect of vinyl chloride exposure on SOD activity, MDA content and GST activity. Serum ADH activity of vinyl chloride exposed workers was significantly higher than that of the control group (P <0.01). The activities of GST and ADH in 30 000 mg ~ group were significantly higher than those in control group (P <0.05). There was a significant dose-response relationship between GST and ADH viability and cumulative exposure dose. Conclusion The current exposure to vinyl chloride at the concentration of vinyl chloride on the body’s oxidative damage was not significant. GST and ADH may be effect biomarkers of exposure to vinyl chloride, but still need further confirmation and discussion.