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目的探讨2型糖尿病肾病与ACE基因I／D多态性关系。方法应用PCR方法检测了36例健康对照者、58例无糖尿病肾病和50例有糖尿病肾病、病程大于5年的2型糖尿病病人的ACE基因I／D基因型。结果三组间ACE基因II、ID、DD三种基因型和I、D两种等位基因的频率分布无显著性差异；在三种基因型之间，尿白蛋白排泄率和血肌研水平也无显著性差异。结论ACE基因I／D多态性与中国汉族2型糖尿病肾病无关联，ACEDD型基因可能不是2型糖尿病病人糖尿病肾病发生和发展的有用的预测标志。
Objective To investigate the relationship between type 2 diabetic nephropathy and ACE gene I / D polymorphism. Methods The ACE gene I / D genotypes of 36 healthy controls, 58 non-diabetic nephropathy and 50 diabetic nephropathy patients with type 2 diabetes mellitus with a disease duration of more than 5 years were detected by PCR. Results There were no significant differences in the frequency distribution of ACE II, ID, DD genotypes and I, D alleles between the three groups. The urinary albumin excretion rate and hemoglobin level were also significantly different among the three genotypes No significant difference. Conclusions ACE gene I / D polymorphism is not associated with type 2 diabetic nephropathy in Chinese Han patients. ACEDD gene may not be a useful predictor of the occurrence and development of diabetic nephropathy in type 2 diabetic patients.