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目的探讨复发转移乳腺癌患者血清HER2水平与组织表达状态间的联系,分析血清HER2检测是否可作为组织HER2检测的补充手段。方法采用酶联免疫吸附试验(ELISA)对72例女性复发转移乳腺癌(组织HER2阳性组30例,组织HER2阴性组42例)和30例健康体检女性(健康对照组)进行血清HER2水平检测,将各组的血清HER2水平进行比较,并与组织HER2表达状态进行对比分析。结果组织HER2阳性组的血清HER2水平显著高于组织HER2阴性组和健康对照组,差异有统计学意义(P<0.0001);组织HER2阴性组血清HER2水平与健康对照组比较差异无统计学意义(P=0.163);组织HER2阳性组有22例血清HER2阳性,阳性符合率为73.4%(22/30),组织HER2阴性组有32例血清HER2阴性,阴性符合率为78.6%(32/42)。血清HER2水平与组织HER2表达状态呈正相关(χ2=21.626,r=0.547)。结论血清HER2水平与组织HER2表达状态呈正相关,且血清HER2可以作为组织HER2检测的补充手段。
Objective To investigate the relationship between serum HER2 level and tissue expression status in patients with recurrent breast cancer and to determine whether serum HER2 level can be used as a complement to detect HER2 in tissues. Methods Serum levels of HER2 were detected in 72 women with recurrent or metastatic breast cancer (HER2-positive group, 30 patients, 42 HER2-negative patients) and 30 healthy women (healthy controls) by enzyme-linked immunosorbent assay (ELISA) The levels of serum HER2 in each group were compared and analyzed with the expression status of HER2 in the tissues. Results The level of HER2 in the HER2 positive group was significantly higher than that in the HER2 negative group and the healthy control group (P <0.0001). There was no significant difference in the serum HER2 level between the HER2 negative group and the healthy control group P = 0.163). HER2-positive group had 22 cases of serum HER2-positive, positive coincidence rate was 73.4% (22/30), HER2-negative group had 32 cases of HER2-negative serum, the negative coincidence rate was 78.6% . The level of serum HER2 was positively correlated with the expression of HER2 (χ2 = 21.626, r = 0.547). Conclusion The level of serum HER2 is positively correlated with the expression of HER2 in the tissue, and serum HER2 can be used as a complement to the tissue HER2 detection.