【摘 要】
：
<正> 从恶性疟原虫基因组测序计划中不断获得的资料,为抗人体恶性疟的深入研究奠定了基础。了解基因序列是认识疟原虫诸如发育、传播、致病、抗药性等基本生物学过程以及鉴定
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<正> 从恶性疟原虫基因组测序计划中不断获得的资料,为抗人体恶性疟的深入研究奠定了基础。了解基因序列是认识疟原虫诸如发育、传播、致病、抗药性等基本生物学过程以及鉴定新的药物和疫苗作用靶分子机制的关键。然而,即便是新近完成测序的恶性疟原虫3D7株,广泛认识这些基因及其在疟原虫生物学方面的作用仍非易事,况且,恶性疟原虫的基因组序列不仅是3D7株的序列,而是相同基因背景的恶性疟原虫变异序列的集合。因此,需要补救方法以确定遗传变异(即序列差异)和它们相应的功能之间的关系。 遗传作图可用于确定生物体有性
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