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在T淋巴细胞不同的活化和分化状态,电压依赖性Kv1.3通道和Ca2+活化IKCa1通道的表达存在差异。细胞从初始状态分化为记忆状态以及从静止转化为激活的过程中,钾通道的表达发生转变。Kv1.3和IKCa1与T细胞活化密切相关,选择性钾通道阻断剂可用于自身免疫性疾病等多种疾病的治疗。本文回顾了钾离子通道在初始T细胞和记忆性T细胞中的功能,描述选择性Kv1.3和IKCa1通道阻断剂的进展以及这些阻断剂潜在的免疫治疗的理论基础。
There are differences in the expression of voltage-dependent Kv1.3 channel and Ca2 + -activated IKCa1 channel in different states of T lymphocyte activation and differentiation. When cells differentiate from an initial state to a memory state and from quiescence to activation, the expression of the potassium channel changes. Kv1.3 and IKCa1 are closely related to the activation of T cells. Selective potassium channel blockers can be used for the treatment of various diseases such as autoimmune diseases. This review reviews the function of potassium channels in naive T cells and memory T cells and describes the progression of selective Kv1.3 and IKCa1 channel blockers and the rationale for potential immunotherapy of these blockers.