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目的探讨加替沙星不良反应(ADR)的特点,为临床合理用药提供参考。方法对我院2004年2月～2007年7月间收集到的100份加替沙星所致ADR报告进行回顾性分析。结果:100例ADR病例报告中,女65例,男35例;涉及11家制药公司4种剂型75个批次的加替沙星药物,其中注射剂引起的ADR93例,占93%;ADR主要有消化系统反应(24.6%)、皮肤损害(22.7%)、神经系统反应(20.9%)。结论加替沙星所致不良反应累及全身多个系统,因此临床应严格控制加替沙星的适用指征,重视该药不良反应引起的危害。
Objective To investigate the characteristics of adverse reactions of gatifloxacin (ADR) and provide a reference for clinical rational drug use. Methods A retrospective analysis of 100 gatifloxacin-induced ADRs collected in our hospital from February 2004 to July 2007 was performed. Results: Among 100 cases of ADR, 65 were women and 35 were men. Gatifloxacin was involved in 75 batches of 4 dosage forms in 11 pharmaceutical companies, of which 93 cases were caused by injection of ADR, accounting for 93%. ADR mainly included Digestive system response (24.6%), skin damage (22.7%), nervous system response (20.9%). CONCLUSIONS: Adverse reactions caused by gatifloxacin involve multiple systems of the whole body. Therefore, the indications for gatifloxacin should be strictly controlled and the hazards caused by adverse reactions of gatifloxacin should be emphasized.