报告了100例闭经患者的细胞遗传学研究,发现异常核型38例,异常率为38%。其中原发性闭经73例,异常核型35例,占47.95%;继发性闭经27例,异常核型3例,占11.11%。并对原发和继发性闭经患者的染色体异常率、发病机理以及核型与表型之间的可能关系进行了探讨。 A report of 100 cases of amenorrhea in patients with cytogenetic studies found that 38 cases of abnormal karyotype, the abnormal rate was 38%. There were 73 cases of primary amenorrhea and 35 cases of abnormal karyotype, accounting for 47.95%. There were 27 cases of secondary amenorrhea and 3 cases of abnormal karyotype, accounting for 11.11%. The relationship between chromosomal aberration rate, pathogenesis, karyotype and phenotype in primary and secondary amenorrhea patients was also discussed.