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目的探讨附有碘-125粒子的食管自膨式支架对晚期食管癌的治疗作用及效果。方法37例晚期(均为Ⅲ、Ⅳ期)食管癌患者分为2组,A组为应用普通自膨式支架治疗,B组应用附有碘-125粒子的自膨式支架进行治疗。术后随访观察支架置入成功率、并发症发生率及生存期。结果 A、B两组支架置入术的成功率均为100％,吞咽困难记分均从3.3分改善到1分,出血及支架移位并发症发生率分别为10.5％、11.1％,两组间无显著性差别(P>0.05)。碘-125粒子自膨式支架组的生存期为10.5个月,明显长于普通自膨式支架组的4.4个月(P<0.001)。结论碘-125粒子自膨式支架除能明显改善吞咽困难症状,还可对肿瘤进行组织间放疗,可明显延长患者的生存期。
Objective To investigate the therapeutic effect and effect of esophageal self-expanding stent with iodine-125 particles on advanced esophageal cancer. Methods Thirty-seven patients with stage Ⅲ and Ⅳ esophageal cancer were divided into two groups. Group A was treated with common self-expandable stents and group B with self-expandable stents with iodine-125 particles. Postoperative follow-up observation of stent placement success rate, complication rate and survival. Results The successful rates of stent implantation in group A and group B were 100%. The score of dysphagia improved from 3.3 to 1, and the complication rates of bleeding and stenting were 10.5% and 11.1% respectively No significant difference (P> 0.05). The survival time of iodine-125 particles self-expandable stent group was 10.5 months, significantly longer than that of ordinary self-expanding stent group 4.4 months (P <0.001). Conclusion Iodine-125 particles self-expanding stent can not only significantly improve the symptoms of dysphagia, but also the tumor tissue interstitial radiotherapy, can significantly prolong the survival of patients.