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目的调查广州市某高校急性胃肠炎暴发疫情感染来源、传播途径及危险因素。方法根据病例定义开展病例搜索,采用病例对照研究探索影响疫情发生的危险因素;标本采用RT-PCR方法检测诺如病毒核酸。结果 2014年11月9~27日该校共发生疑似诺如病毒感染性腹泻病例667例,罹患率为6.0%,18~23日为发病高峰。采集病例及厨工肛拭子及环境涂抹标本247份,其中诺如病毒核酸阳性65份。病例对照显示接触过同类病人(OR=1.41,95%CI=1.05~1.98),发病当天(OR=1.60,95%CI=1.02~2.49)及发病前天(OR=1.55,95%CI=1.02~2.37)曾经在第三食堂吃饭为发病的独立危险因素。结论该起疫情为诺如病毒引起的急性胃肠炎暴发。
Objective To investigate the origin, route of transmission and risk factors of acute gastroenteritis outbreak in a college in Guangzhou. Methods According to the definition of case, the case search was carried out. Case-control studies were conducted to explore the risk factors that affected the outbreaks. The samples were tested for the presence of Norovirus nucleic acid by RT-PCR. Results A total of 667 cases of norovirus infectious diarrhea were found in the school from November 9 to November 2014, with an attack rate of 6.0% and a peak incidence of 18 to 23 days. A total of 247 samples of swabs and kitchen swabs, including 65 Norovirus positive samples, were collected. The case control showed that the patients who were exposed to the same type of patients (OR = 1.41, 95% CI = 1.05-1.98) had the highest morbidity (OR = 1.60,95% CI = 1.02-2.49) 2.37) Eating at the third cafeteria was an independent risk factor for the disease. Conclusion The outbreak was Norovirus-induced acute gastroenteritis outbreak.