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[目的]探讨苯海索对重症有机磷农药中毒并发肌张力增高患者的影响。[方法]选择重症有机磷农药中毒并发肌张力增高患者70例,随机分为治疗组(36例)和对照组(34例)。对照组常规给予洗胃、特殊解毒药、对症及支持治疗。治疗组患者在对照组治疗的基础上,同时给予苯海索3次/d,每次2 mg,疗程3~31 d。[结果]治疗组患者呼吸衰竭发生率为19.5%,迟发性神经病发生率为5.6%,各低于对照组的70.6%、50.0%,差异均有统计学意义(P<0.01);治疗组死亡率为2.7%,低于对照组的14.7%,但差异无统计学意义(P>0.05)。治疗组存活患者平均住院时间为(15.9±3.0)d,短于对照组存活患者的(27.3±3.6)d,差异有统计学意义(P<0.01)。[结论]苯海索对重症有机磷农药中毒并发肌张力增高患者疗效较好,值得推广。
[Objective] To investigate the effect of trihexyphenidyl on patients with severe organophosphorus pesticide poisoning complicated with hypertonia. [Methods] Seventy patients with severe organophosphorus pesticide poisoning complicated with hypertonia were randomly divided into treatment group (36 cases) and control group (34 cases). The control group was given routine gastric lavage, special antidotes, symptomatic and supportive treatment. Treatment group patients in the control group based on the treatment, while given trihexyphenidyl 3 times / d, each 2 mg, treatment for 3 ~ 31 d. [Results] The incidence of respiratory failure in treatment group was 19.5%, the incidence of delayed neuropathy was 5.6%, which was lower than 70.6% and 50.0% in control group (P <0.01). The treatment group The mortality rate was 2.7%, lower than the control group 14.7%, but the difference was not statistically significant (P> 0.05). The mean length of stay of patients surviving in the treatment group was (15.9 ± 3.0) d, which was shorter than that in the control group (27.3 ± 3.6) d, the difference was statistically significant (P <0.01). [Conclusion] Phenoxyethanol is effective in patients with severe organophosphorus pesticide poisoning complicated with hypertonia, which is worth to be popularized.