Positive Pressure Protective Clothing (PPPC) is the most important personal protective equipment for BSL-4 laboratory and a primary barrier to avoid exposure to pathogenic microorganisms. However, during the process of storage, utilization, disinfection and inspection, it will be inevitable damaged in varying degrees. PPPC is expensive; therefore, effective repairs become an important procedure to prolong service life of PPPC and to ensure their protective function. This paper analyzed those common damages in PPPC during routine BSL-4 laboratory operations and provided repair plans which can be used as references for users and maintenance personnel.