GC结合因子2(GC-binding factor 2,GCF2)是一种转录抑制因子,因为能与表皮生长因子受体(epidermal growth factor receptor,EGFR)基因启动子上富含GC的序列结合而得名[1]。研究表明,GCF2可通过多种途径参与细胞增殖、细胞周期调控及细胞凋亡等进程[2-4]。GCF2广泛地高表达于肺癌A549细胞、胃腺瘤AGS细胞及白血病K562细胞等人类多种肿瘤细胞,并且发现GCF2在这些细胞中的 GC-binding factor 2 (GCF2) is a transcriptional repressor named after its binding to the GC-rich sequence on the epidermal growth factor receptor (EGFR) gene promoter [ 1]. Studies have shown that GCF2 can participate in processes such as cell proliferation, cell cycle regulation and apoptosis through a variety of pathways [2-4]. GCF2 is widely expressed in a wide variety of human tumor cells such as lung cancer A549 cells, gastric adenoma AGS cells and leukemia K562 cells, and GCF2 is found to be highly expressed in these cells