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目的探讨CA125、OPN和YKL-40在卵巢上皮性肿瘤中的表达及相关性。方法采用免疫组化的方法检测13例正常卵巢组织、20例卵巢良性肿瘤组织、20例卵巢交界性肿瘤组织、40例卵巢癌组织标本中CA125、OPN和YKL-40的表达情况,分析三者表达与临床分期、病理分级及患者生存率之间的关系。结果CA125、OPN和YKL-40在卵巢癌组织中的表达显著高于卵巢交界性及良性肿瘤组织,各组比较差异具有统计学意义(P<0.05)。CA125、OPN和YKL-40在卵巢浆液性囊腺癌中的阳性率均高于黏液性囊腺癌(均P<0.05)。三者在卵巢癌组织中的阳性表达率随细胞分化程度的降低而显著升高,Ⅲ-Ⅳ期卵巢癌中三指标的阳性表达率均显著高于卵巢癌Ⅰ-Ⅱ期,且CA125、OPN和YKL-40表达阳性者均伴有较高的淋巴转移率,差异均有统计学意义(P<0.05)。结论CA125、OPN和YKL-40在卵巢浆液性囊腺癌组织中高表达,三者较高的表达率和卵巢肿瘤较晚的临床分期、较高的病理分级和淋巴转移率及患者的不良预后密切相关。
Objective To investigate the expression and correlation of CA125, OPN and YKL-40 in epithelial ovarian tumors. Methods The expression of CA125, OPN and YKL-40 in 13 cases of normal ovarian tissue, 20 cases of ovarian benign tumor, 20 cases of ovarian borderline tumor and 40 cases of ovarian cancer were detected by immunohistochemistry. Expression and clinical stage, pathological grade and the relationship between patient survival rate. Results The expressions of CA125, OPN and YKL-40 in ovarian cancer tissues were significantly higher than those in ovarian border and benign tumor tissues, with statistical significance (P <0.05). The positive rates of CA125, OPN and YKL-40 in ovarian serous cystadenocarcinoma were higher than those in mucinous cystadenocarcinoma (all P <0.05). The positive rates of three markers in ovarian cancer tissues were significantly increased with the decrease of cell differentiation. The positive rates of three markers in stage Ⅲ-Ⅳ ovarian cancer were significantly higher than those in stage Ⅰ-Ⅱ ovarian cancer, and the expressions of CA125, OPN And those with positive YKL-40 expression were associated with higher lymph node metastasis rates (all P <0.05). Conclusions The expression of CA125, OPN and YKL-40 is overexpressed in ovarian serous cystadenocarcinoma. The high expression rate of the three and the later clinical stage, higher pathological grade and lymph node metastasis, and the poor prognosis of patients with ovarian cancer Related.