传统概念将山莨菪碱(Anisodamine,代号654及654-2)列为抗胆碱药,用后引起心率(HR)加速,心缩加强。但我们曾给急性心肌缺血麻醉犬静注654-2 10mg/kg 观察到对心脏的负变时性、负变力性作用以及动脉血压(ABP)降低,与传统认识不同。山莨菪碱临床治疗休克等危重疾病虽已取得较好效果,但于动物所用剂量范围对心 The traditional concept of Anisodamine (Anisodamine, code 654 and 654-2) as anti-cholinergic drugs, used to cause heart rate (HR) acceleration, enhanced cardiac contractility. However, we have given intravenous injection of 654-2 10 mg / kg to acute myocardial ischemia anesthesia dogs, which have negative concomitant effects on the heart, negative inotropic effects and arterial blood pressure (ABP). Anisodamine clinical treatment of shock and other critical diseases have achieved good results, but the range of doses used in animals on the heart