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目的了解广西白裤瑶族地区居民心理应激状况及其与血清8-OHd G的关系。方法应用自编生活方式调查表、生活事件量表(LES)、简化症状自评量表、社会支持评定量表(SSRS)对164名白裤瑶族和160名壮族居民进行问卷调查,同时应用酶联免疫吸附法(ELISA)检测血清8-OHd G含量。结果生活事件总分≥20分者占32.41%,心理问题阳性检出率为26.12%;社会支持总均分为(8.55±1.69)分。壮族和白裤瑶族焦虑因子分别为(1.66±0.69)和(1.43±0.42)分,女性和男性分别为(1.65±0.66)和(1.44±0.46)分,差异均有统计学意义(P<0.05)。血清8-OHd G平均水平为(0.28±0.10)ng/m L,不同民族、文化程度、年龄居民血清8-OHd G水平差异有统计学意义(P<0.05)。8-OHd G水平与躯体化、焦虑、抑郁呈正相关,与社会支持利用度、社会支持总分呈负相关(P<0.05)。多元线性回归分析显示,躯体化(b=0.035,β=3.625,P<0.01)和社会支持的利用度(b=-0.204,β=-2.192,P<0.05)2个影响因素进入8-OHd G的回归方程,二者可以解释8-OHd G 9.60%的变异量。结论广西壮瑶民族居民血清8-OHd G水平与心理应激和社会支持因素相关,血清8-OHd G水平的检测可能是早期发现心理应激的生物指标。
Objective To understand the psychological stress and its relationship with serum 8-OHd G in Baiku Yao ethnic group in Guangxi province. Methods A total of 164 White Trousers and 160 Zhuang residents were surveyed by self-compiled Life Style Questionnaire, Life Events Scale (LES), Simplified Symptom Checklist 90 (SSRS) and Social Support Rating Scale (SSRS) Serum 8-OHd G level was detected by ELISA. Results The total score of life events was 20.41%, the positive rate of psychological problems was 26.12%. The total social support was (8.55 ± 1.69) points. The anxiety factors in Zhuang and Baiku Yao ethnic groups were (1.66 ± 0.69) and (1.43 ± 0.42) points respectively, and the difference was statistically significant (1.65 ± 0.66) and (1.44 ± 0.46) points for females and males ). The mean level of 8-OHd G in serum was (0.28 ± 0.10) ng / m L, and there was significant difference in serum 8-OHd G among different ethnic groups, educational level and age (P <0.05). The level of 8-OHd G was positively correlated with somatization, anxiety and depression, negatively correlated with social support utilization and social support scores (P <0.05). Multivariate linear regression analysis showed that two influencing factors of somatization (b = 0.035, β = 3.625, P <0.01) and social support utilization (b = -0.204, β = -2.192, P <0.05) entered 8-OHd G regression equation, both of which can explain the variation of 8-OHd G 9.60%. Conclusion Serum 8-OHd G levels in Zhuangyao ethnic group in Guangxi are related to psychological stress and social support factors. The detection of serum 8-OHd G level may be the biological indicator of early detection of psychological stress.