本文为儿童狼疮肾炎病例长期系统的环磷酰胺静脉点滴疗法的研究,报道了治疗1年后的病情结果,以确定此治疗剂量、进度是否安全有效。病人和方法全部16名(男1、女15)病例,年龄4～18岁,符合全身性红斑狼疮(SLE)诊断指标。环磷酰胺静脉点滴疗法指征为:活动性狼疮肾炎病儿,用皮质甾类药物治疗而肌酐廓清率(Crcl)为100mg/ml/min/1.75m~2以下;弥漫性增殖性肾 This article is a long-term systematic study of cyclophosphamide intravenous drip therapy in children with lupus nephritis and reports the results of the disease after 1 year of treatment to determine whether the treatment dose, the progress is safe and effective. All 16 patients (male 1, female 15) with age ranged from 4 to 18 years were eligible for diagnosis of systemic lupus erythematosus (SLE). Cyclophosphamide intravenous drip therapy indications are: active lupus nephritis in children with corticosteroids and creatinine clearance rate (Crcl) of 100mg / ml / min / 1.75m ~ 2 or less; diffuse proliferative kidney