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目的:优选活血康脑胶囊制备工艺中黄芪提取过程中的有关工艺参数。方法:以黄芪甲苷含量为指标,HPLC法为测定方法,提取率为评价标准,采用重复正交实验法优化提取工艺。结果:乙醇浓度、提取时间、提取次数均对提取率有显著的影响,溶剂倍量影响不大。结论:黄芪最佳提取工艺条件为加8倍量90%乙醇,回流提取3次,每次1h。
OBJECTIVE: To optimize the relevant technological parameters in the extraction process of Radix Scutellariae in the preparation process of Huoxue Kangnao capsule. Methods: The content of astragaloside was used as the index, and HPLC method was used as the determination method. The extraction rate was the evaluation standard. The orthogonal experiment was used to optimize the extraction process. Results: The ethanol concentration, extraction time, and extraction times all had significant effects on the extraction rate, and the solvent amount had little effect. Conclusion: The optimum extraction conditions of Astragalus membranaceus were 8 times of 90% ethanol, reflux extraction 3 times, each time 1h.