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目的:探讨帕金森患者的临床特征及其治疗方式。方法:回顾性分析了2008.12-2011.12入住我院精神内科的120例帕金森患者的临床资料,采汉密尔顿抑郁量表(HAMA)对其抑郁情况进行评分,以了解其临床特征。并将本组患者随机性地均分为对照组与观察者两组,对照组(n=60)以茴拉西坦进行治疗,观察组(n=60)给予氟西汀治疗,对比两组患者的临床疗效以及治疗后患者的生存质量,组间差异以P<0.05表示具有统计学意义。结果:(1)帕金森综合症患者的主要临床特征为运动功能出现障碍,且易并发抑郁症状;(2)治疗后对照组与观察组两组患者的MMSE、ADL以及ADAS-cog等评分均存在显著的统计学差异(P<0.01);(3)对照组与观察者患者治疗后的生存质量总得分为(103±6)分(,134±8)分,二者具有显著的统计学差异(P<0.01)。结论:帕金森综合症主要会导致患者运动性障碍的发生,且最容易产生抑郁症。对其治疗的最为有效的药物为氟西汀,应该在临床上加以推广并应用。
Objective: To investigate the clinical characteristics and treatment of Parkinson’s disease. Methods: The clinical data of 120 Parkinson patients admitted to our hospital from December 2008 to December 2011 were retrospectively analyzed. The Hamilton Depression Rating Scale (HAMA) was used to assess their depression to find out their clinical features. The patients were randomly divided into control group and observer group. The control group (n = 60) was treated with aniracetam. The observation group (n = 60) received fluoxetine. The clinical efficacy of patients and the quality of life of patients after treatment, the difference between groups with P <0.05 expressed statistically significant. Results: (1) The main clinical features of patients with Parkinson’s disease were dyskinesia and depressive symptoms; (2) The scores of MMSE, ADL and ADAS-cog in control and observation groups after treatment were (P <0.01). (3) The total quality of life scores of the control group and the observer group after treatment were (103 ± 6) points (134 ± 8) points, both of which had significant statistic Difference (P <0.01). Conclusions: Parkinson’s disease predominantly leads to motility disorders in patients and is most likely to develop depression. Fluoxetine is the most effective drug for its treatment and should be popularized and applied clinically.