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目的 研究PTHrP在肿瘤发生过程中的作用以及PTHrP和P5 3在结肠腺癌中表达的关系。方法 用免疫组织化学ABC法对 6 8例结肠组织 (30例结肠腺癌 ,2 0例腺瘤性息肉 ,18例正常结肠组织 )进行PTHrP检测 ,并对其中 30例结肠腺癌进行P5 3检测。结果 结肠癌组PTHrP的阳性率明显高于腺瘤组 (P <0 0 5 )和正常组 (P <0 0 1)。结肠癌高中分化组与低分化组PTHrP的阳性率无显著差异 (P >0 0 5 ) ,PTHrP与P5 3的表达有相关关系 (P <0 0 5 )。结论 PTHrP的过度表达与细胞的恶性转化有关 ,与肿瘤分化程度无明显关系 ,PTHrP与P5 3可能在肿瘤的发生发展过程中共同发挥作用
Objective To study the role of PTHrP in tumorigenesis and the relationship between PTHrP and P53 in colon adenocarcinoma. Methods Immunohistochemical ABC method was used to detect PTHrP in 68 cases of colon tissue (30 cases of colon adenocarcinoma, 20 cases of adenomatous polyp, 18 cases of normal colon tissue), and 30 cases of colon adenocarcinoma were tested for P53. . Results The positive rate of PTHrP in colon cancer group was significantly higher than that in adenoma group (P <0 05) and normal group (P <0 01). There was no significant difference in the positive rate of PTHrP between the differentiated and poorly differentiated colon cancer patients (P > 0.05). There was a correlation between PTHrP and P53 expression (P < 0.05). Conclusion The over-expression of PTHrP is related to the malignant transformation of cells and has no obvious relationship with the degree of tumor differentiation. PTHrP and P53 may play a role in the development of tumors.