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对50例经病原学检测确诊的乙型病毒性肝炎患者，测定了血清肿瘤坏死因子（TNF）－α的水平，结果显示，慢性中、重型乙型病毒性肝炎患者血清中TNF－α明显高于慢性轻型患者（P＜0．05）；HBV－DNA阳性的患者，血清TNF－α的含量也明显高于阴性者。结果提示，测定血清TNF－α有助于估计乙肝病人病情的严重性和预后。
Serum levels of tumor necrosis factor-α (TNF-α) were measured in 50 patients diagnosed with etiological diagnosis of hepatitis B virus. The results showed that serum TNF-α was significantly higher in patients with chronic hepatitis B and severe hepatitis B In chronic mild type (P <0.05), the level of serum TNF-α in HBV-DNA positive group was significantly higher than that in negative group. The results suggest that the determination of serum TNF-α helps to estimate the severity and prognosis of hepatitis B patients.