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目的:研究妊娠期高血压疾病患者24 h尿蛋白含量与动态血压的关系,以指导临床。方法:对16例妊娠期高血压疾病患者和16例正常女性分别进行24 h尿蛋白测定,白天和晚上的动态血压检测,分析尿蛋白与动态血压的相关性。结果:妊娠期高血压疾病患者的尿蛋白含量明显大于正常人(P<0.01);患者白天、晚上时的收缩压、舒张压和平均动脉压都明显高于正常人(P<0.05),患者与正常人白天的收缩压和平均动脉压明显高于晚上(P<0.05)。患者和正常人的血压值和24 h尿蛋白无相关性(P>0.05)。结论:妊娠期高血压疾病患者24 h尿蛋白含量升高,但是血压昼夜节律还是存在的。
Objective: To study the relationship between 24-h urinary protein and ambulatory blood pressure in patients with gestational hypertension and to guide the clinical practice. Methods: Urine protein was measured in 24 patients with gestational hypertension and 16 normal women. Urine protein was measured with ambulatory blood pressure during day and night. The correlation between urinary protein and ambulatory blood pressure was analyzed. Results: Urinary protein in hypertensive disorder complicating pregnancy was significantly higher than that in normal controls (P <0.01). The systolic blood pressure, diastolic blood pressure and mean arterial pressure were significantly higher in patients with gestational hypertension than those in normal controls (P <0.05) Systolic blood pressure and mean arterial pressure were significantly higher in the daytime than in the evening (P <0.05). There was no correlation between blood pressure and 24 h urinary protein in patients and normal subjects (P> 0.05). Conclusion: Urinary protein in 24 h patients with hypertensive disorder complicating pregnancy increased, but circadian blood pressure still existed.