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目的巩固肠线虫病低感染地区的防治成效。方法针对低感染地区人群感染肠线虫的流行病学特点,对高危人群采取目标化疗,以阿苯达唑和甲苯达唑各200mg顿服,以饱和盐水浮聚法(查3片)和定量透明法(查2片)评价疗效。结果选择200人左右作为目标化疗对象,连续3年每年一次,肠线虫感染率由6.20％分别降至5.37％和3.21％,间隔3年后复查,感染率为2.29％。小学生目标化疗每年一次连续5年,蛔虫和鞭虫的感染率分别由1.39％和4.18％降至0.90％和1.35％,钩虫感染率由10.8％降至5.04％。钩虫易感人群的目际化疗使41岁以上人群钩虫感染率由19.38％降至10.89％。结论特定人群一年一次目标化疗,连续3年,肠线虫感染率呈逐年下降,而且间隔3年未见回升,防治效果可以巩固。小学生目标化疗每年一次连续5年,蛔虫和鞭虫的感染率呈下降趋势;钩虫易感人群目标化疗,钩虫感染率下降。表明在肠线虫病低感染地区,目标化疗是一种有效的防治新措施。
Objective To consolidate the prevention and treatment of intestinal nematode disease in areas with low infection. Methods According to the epidemiological characteristics of intestinal nematode infection in low-risk population, targeted chemotherapy was given to high-risk groups with 200 mg of albendazole and mebendazole respectively, Law (check 2 tablets) evaluation of efficacy. Results 200 patients were selected as the target of chemotherapy. The infection rates of intestinal nematodes decreased from 6.20% to 5.37% and 3.21% respectively after 3 consecutive years. The infection rate after 3 years was 2.29%. The target rate of primary and secondary school students was continuously decreased from 1.39% and 4.18% to 0.90% and 1.35% respectively after 5 years of targeted chemotherapy. The infection rate of hookworm decreased from 10.8% to 5.04%. The target chemotherapy of hookworm susceptible population reduced the hookworm infection rate from 19.38% to 10.89% in people over 41 years of age. Conclusions Specific target group chemotherapy once a year for three consecutive years, intestinal nematode infection rate showed a declining year by year, but no recovery after 3 years, the control effect can be consolidated. The target chemotherapy for primary school students once a year for 5 consecutive years, the infection rate of roundworms and whipworms showed a downward trend; hookworm susceptible population target chemotherapy, hookworm infection decreased. This indicated that in the areas of low infection of gut nematode, target chemotherapy is an effective new prevention and cure measure.