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本文对比观察了用谷尘、青霉菌提取液和卵蛋白致敏并激发后阳性反应豚鼠支气管肺泡灌洗液（ＢＡＬＦ）内细胞学和肺组织病理学变化。结果发现激发试验阳性的谷尘组、青霉菌组和卵蛋白组哮喘模型ＢＡＬＦ内嗜酸细胞数分别为３６．０４±１１．２２％，３２．２１±８．２４％和３０．５０±１０．２０％，均非常显著地高于反应阴性组（１２．５０±７．２９％）和对照组（９．７５±４．０３％），Ｐ＜０．０１。光镜下见反应阳性动物支气管、细支气管痉挛以及壁内和腔内大量炎细胞浸润和粘液栓塞等。电镜下可见以嗜酸细胞为主的炎性细胞及其胞浆内大量特异性颗粒及脱颗粒后形成的空泡等，提示嗜酸细胞在谷物粉尘所致豚鼠哮喘的发病过程中起着重要的作用。
In this paper, we compared the cytology and lung histopathology in guinea pig bronchoalveolar lavage fluid (BALF) that were sensitized and challenged with Gu and Chen, Penicillium sp. And egg protein. The results showed that the numbers of eosinophils in the BALF of asthmatic model group were 36.04 ± 11.22%, 32.21 ± 8.24% and 30.50 ± 10 .20%, all of which were significantly higher than that of negative group (12.50 ± 7.29%) and control group (9.75 ± 4.03%), P <0.01. Light microscope, see reaction-positive animals bronchus, bronchial spasm and a large number of intra-and parietal inflammatory cell infiltration and mucus embolism. Electron microscopy showed eosinophil-based inflammatory cells and a large number of specific cytoplasmic granules and vacuoles formed after degranulation, suggesting that eosinophils play an important role in the pathogenesis of cereal dust-induced guinea pig asthma Role.