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目的:研究来氟米特与甲氨蝶呤联合用药对严重类风湿关节炎临床症状,特别是对关节损害的作用。方法:86例严重类风湿关节炎患者随机分为来氟米特组、来氟米特+甲氨蝶呤组,治疗前作相应的临床、实验室及影像学检查,疗程为6个月,对两组治疗方案在3个月、6个月时的疗效及观察指标进行评估。结果:来氟米特组、来氟米特+甲氨蝶呤组治疗6个月后,关节疼痛数明显减少,关节肿胀亦得到明显改善,晨僵时间显著缩短,其中尤以来氟米特+甲氨蝶呤效果明显,但血沉及C反应蛋白改变不显著。结论:来氟米特+甲氨蝶呤联合用药对严重类风湿关节炎的临床症状及关节损害的改善具有明显的效果。
OBJECTIVE: To study the effects of combination of leflunomide and methotrexate on clinical symptoms of severe rheumatoid arthritis, especially joint damage. Methods: A total of 86 patients with severe rheumatoid arthritis were randomly divided into leflunomide group and leflunomide + methotrexate group. Before treatment, corresponding clinical, laboratory and imaging studies were performed. The course of treatment was 6 months. Two groups of treatment options at 3 months, 6 months of efficacy and observation indicators were evaluated. Results: Leflunomide group, leflunomide + methotrexate group after 6 months of treatment, the number of joint pain was significantly reduced joint swelling also been significantly improved, morning stiffness significantly reduced, especially leflunomide + Methotrexate obvious effect, but ESR and C-reactive protein changes were not significant. Conclusion: The combination of leflunomide and methotrexate has obvious effect on the clinical symptoms and the joint damage of severe rheumatoid arthritis.