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目的研究131碘(131I)治疗分化型甲状腺癌引起唾液腺损伤的评估方法,以及有效预防或减轻131I对唾液腺损伤的干预措施。方法将60例接受131I治疗的分化型甲状腺癌患者分为两组,观察组和对照组各30例。观察组采取综合干预方法,在治疗期间大量饮用酸性饮料,休息时行自我暗示疗法;对照组治疗期间口含维生素C片并大量饮水。通过问卷调查评估患者口干症状、口干程度,应用99m锝(99mTcO4-)唾液腺动态显像评估131I不同累计剂量唾液腺功能损伤程度,对两组口干症状、程度和唾液腺功能损伤程度进行比较。结果随着131I治疗累计剂量的增加,两组口干症状、程度和唾液腺受损率也明显增加,两组口干症状、程度和唾液腺功能损伤程度的差异无统计学意义。结论分化型甲状腺癌患者在131I治疗期间,采取综合干预措施与口含维生素C片的方法在保护患者唾液腺功能方面效果相似,综合干预措施可以替代口含维生素C片。
Objective To investigate 131I treatment of differentiated thyroid cancer caused by salivary gland injury assessment methods, and to effectively prevent or mitigate 131I damage to the salivary glands intervention. Methods Sixty patients with differentiated thyroid cancer undergoing 131I treatment were divided into two groups, 30 cases in the observation group and the control group. Observation group to take a comprehensive intervention, during the treatment of drinking a large number of acidic drinks, rest line self-cue therapy; control group during the mouth with vitamin C tablets and plenty of water. The degree of salivary gland dysfunction in different cumulative dose of 131I was evaluated by 99mTcO4- (99mTcO4-) salivary gland dynamic imaging through questionnaire to evaluate the degree of dry mouth and dry mouth of the patients. The degree of salivary gland dysfunction and degree of salivary gland function were compared between the two groups. Results With the cumulative dose of 131I treatment, the symptoms and degree of dry mouth and the rate of salivary gland damage were significantly increased in both groups. There was no significant difference between the two groups in the degree of dry mouth symptoms and degree of salivary gland dysfunction. Conclusion In the patients with differentiated thyroid cancer during 131I treatment, the comprehensive interventions and oral vitamin C tablets are effective in protecting the salivary gland function of patients, and the comprehensive interventions can replace the oral vitamin C tablets.