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舒更葡糖钠是一种人工合成的γ-环糊精类衍生物，可以快速拮抗非去极化肌松药所引起的神经肌肉阻滞。近年来关于舒更葡糖钠不良反应的报道越来越多，文章主要介绍舒更葡糖钠不良反应方面的研究新进展，包括最常见且最严重的不良反应，如术后肌松残余、过敏反应、凝血功能障碍、心血管作用、支气管痉挛和喉痉挛等，其他不良反应如术后恶心呕吐、肾排泄时间延长、线粒体依赖的神经细胞凋亡和金属味异常味觉等，为舒更葡糖钠在肌松拮抗领域的合理应用提供相应临床参考。“,”Sugammadex is a synthetic γ-cyclodextrin derivative to reverse steroidal neuromuscular blocking agents. However, there are still many reports on the adverse effects of sugammadex in recent years. This article mainly introduces the new clinical application on the adverse effects of sugammadex in recent years. The most severe and common adverse effects are residual neuromuscular block, hypersensitivity, coagulation disorders, cardiovascular action, bronchospasm and laryngospasm, and other adverse effects including nausea and vomiting, prolonged renal excretion, mitochondrial-dependent neuronal apoptosis, and metallic taste. This article provides a corresponding clinical reference for sugammadex rational application in the antagonistic muscle relaxation field.