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目的观察美托洛尔联合卡托普利、螺内酯治疗慢性心力衰竭的疗效与安全。方法选取102例慢性心力衰竭的患者,随机分为治疗组(52例)与对照组(50例),治疗组在应用卡托普利、螺内酯及其他常规治疗的基础上加美托洛尔,对照组给予卡托普利、螺内酯等常规治疗。治疗并随访观察6个月,监测治疗前后心率、血压、心功能、超声心动图各项参数和治疗后6 min步行试验。结果治疗组心功能、超声心动图、6 min步行试验与对照组相比差异有统计学意义(P<0.05)。结论在应用卡托普利、螺内酯及其他常规治疗慢性心力衰竭的基础上加用美托洛尔可提高疗效及运动耐受量。
Objective To observe the efficacy and safety of metoprolol combined with captopril and spironolactone in the treatment of chronic heart failure. Methods A total of 102 patients with chronic heart failure were randomly divided into treatment group (n = 52) and control group (n = 50). The treatment group was treated with captopril, spironolactone and other conventional treatments based on metoprolol, Group given captopril, spironolactone and other conventional treatment. The patients were followed up for 6 months. The heart rate, blood pressure, heart function, echocardiographic parameters and walking test at 6 min after treatment were monitored before and after treatment. Results The cardiac function, echocardiography and 6-minute walking test in the treatment group had significant differences compared with the control group (P <0.05). Conclusion The application of captopril, spironolactone and other conventional treatment of chronic heart failure based on the use of metoprolol can improve the efficacy and exercise tolerance.