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分别采用血清学分型和基因序列分析方法对1996~1997年收集的72份标本进行人类免疫缺陷病毒1型(HIV-1)亚型鉴别分析,证实我区存在着HIV-1B′、C、D和E4种基因亚型。在有偿供血者中以B′亚型感染为主和个别的D亚型感染,并散发于全区,而C亚型则在吸毒人群中流行,E亚型仅在中越边境地区吸毒人群中流行,形成我国新的HIV-1基因亚型流行区。分析了我区HIV-1的传染来源及不同亚型病毒混合流行对今后趋势的影响。
Serological typing and sequence analysis were used to analyze the subtypes of HIV-1 in 72 samples collected from 1996 to 1997, confirming the presence of HIV-1B ’, C, D And E4 genotypes. Among compensated blood donors, infection with predominantly B ’subtype and individual subtypes D were distributed throughout the region while subtype C was endemic among drug users, while subtype E was endemic only among drug abusers in the border between China and Vietnam , Forming a new genotype of HIV-1 in China. The source of HIV-1 infection in our district and the impact of different subtypes of the virus on future trends were analyzed.