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高血压时的左室肥大,是心脏对后负荷增高的一种代偿机理,它是心血管疾病和死亡的危险因素。ACE抑制剂,在降压的同时能减轻左室肥大。阿拉普利(alacepril)比卡托普利起效迟,抗高血压作用时间长。 10例原发性高血压伴左室肥大,口服阿拉普利25mg每日2次(必要时增至50mg每日2次),共治疗12个月。治疗前后作超声心动图。治疗12个月后,收缩压、舒张压、平均压均显著下降(p值皆<0.01),心率无明显变化。左室舒张末期内径无明显变化,但收缩末期内径明显缩小(P<0.01)。左室重
Left ventricular hypertrophy during hypertension is a compensatory mechanism of increased cardiac afterload, which is a risk factor for cardiovascular disease and death. ACE inhibitors, while reducing blood pressure can reduce left ventricular hypertrophy. Alacepril is more effective than Bikantopril, antihypertensive effect of a long time. 10 cases of essential hypertension with left ventricular hypertrophy, oral alapril 25mg twice daily (if necessary, to 50mg twice daily) for a total of 12 months. Echocardiography before and after treatment. Systolic blood pressure, diastolic blood pressure and mean pressure decreased significantly after 12 months of treatment (all p <0.01), but no significant changes in heart rate. Left ventricular end-diastolic diameter did not change significantly, but the end-systolic diameter was significantly reduced (P <0.01). Left ventricular weight