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霉菌在空气中分布极广,种类繁多。根据国内外不同地区霉菌分布的调查及皮肤试验等研究结果证实,霉菌是主要的吸入性变应原之一。故从优势霉菌中提取制备其变应原成分,用以进行变应原理化及生物学活性的分析,以及临床对霉菌过敏患者的特异诊断和治疗,具有一定的理论与实用价值。 目前国际上对霉菌变应原的研究已相当深入。国内也开展了此项研究工作,但迄今为止所用的诊断及治疗制剂仍以变应原粗提液为主,而对于霉菌变应原的进一步纯化及分析研究尚很欠缺。本实验根据我国丹东地区空气中霉菌分布的调查结果,选择制备了分布较多的十种霉菌变应原粗提物,并对其中分布最多的交链孢霉进行了纯化分析。
Molds are extremely widespread in the air, with a wide variety of species. Based on investigations of mold distribution and skin tests in different regions at home and abroad, it was confirmed that mold is one of the major inhalant allergens. Therefore, the allergen component is extracted and prepared from the dominant mold for the analysis of the principle of allergies and biological activity, as well as the clinical specific diagnosis and treatment of patients with mold allergy, and has certain theoretical and practical value. At present, research on mold allergens in the world has been quite thorough. The research work has also been carried out in China, but the diagnostic and therapeutic preparations used so far are still mainly crude extracts of allergens, and further purification and analysis of the allergens of moulds are still lacking. Based on the investigation results of mold distribution in the air in Dandong, China, this experiment selected and prepared ten kinds of mold allergen crude extracts with large distribution, and purified and analyzed the most widely distributed Alternaria alternata.