肿瘤的发生、发展与细胞增殖和凋亡失衡密切相关。凋亡调控失常导致的细胞增殖过度和凋亡不足是肿瘤形成的重要机制之一,也是影响肿瘤治疗及预后的重要因素。细胞凋亡受多种基因调控,凋亡抑制蛋白(inhibitor of apoptosis protein,IAP)家族是一类重要的内源性凋亡抑制因子,目前 The occurrence and development of tumor are closely related to the unbalance of cell proliferation and apoptosis. Apoptosis control disorders caused by excessive cell proliferation and lack of apoptosis is an important mechanism of tumor formation, but also affect the tumor treatment and prognosis of the important factors. Apoptosis is regulated by many genes. The inhibitor of apoptosis protein (IAP) family is an important type of endogenous apoptosis inhibitor. At present,