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目的：探讨度洛西汀与文拉法辛治疗产后抑郁症的疗效和安全性。方法将80例产后抑郁症患者随机分为两组，每组40例，研究组口服度洛西汀治疗，对照组口服文拉法辛治疗，观察4周。于治疗前后采用汉密顿抑郁量表评定临床疗效，副反应量表评定不良反应。结果治疗2周末起两组汉密顿抑郁量表评分均较治疗前显著下降（P＜0．01），治疗4周末研究组总有效率为85．0％、对照组为82．5％，两组比较差异无显著性（ P＞0．05）。两组不良反应主要表现为恶心、出汗、心动过速、失眠等，副反应量表评分比较差异无显著性（P＞0．05）。结论度洛西汀与文拉法辛治疗产后抑郁症疗效显著，安全性高，依从性好。“,”Objective To explore the efficacy and safety of duloxetine and venlafaxine in the treatment of postpartum depression (PD) .Methods Eighty PD patients were randomly assigned to two groups of 40 ones each ,research group took orally duloxetine and control group did venlafaxine for 4 weeks .Efficacies were assessed with the Hamilton Depression Scale (HAMD) before and after treatment and adverse reac‐tions with the Treatment Emergent Symptom Scale (TESS) .Results Since the end of the 2nd week the HAMD scores of both groups lowered more significantly compared with pretreatment (P0 .05) .Adverse reactions of both groups were mainly nausea ,perspiration ,tachycardia ,insomnia and so on ,there was no significant group difference in the TESS score (P> 0 .05) .Conclusion Duloxetine and venlafaxine have an evident effect ,higher safety and better compliance in postpartum depression .