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目的采用单光子发射型计算机断层(SPECT)显像技术研究缺血存活心肌与缺氧诱导因子-1((HIF-1α)和血管内皮生长因子(VEGF)变化的相关性。方法201Tl再分布显像判断心肌梗死患者缺血存活心肌的多寡;再以ELISA法检测患者HIF-1α和VEGF水平,并分析201Tl显像检测缺血存活心肌与HIF-1α和VEGF的相关性。结果 SPECT显像检测获得的缺血存活心肌总积分与血清HIF-1α、VEGF水平变化显著相关(均P<0.001)。结论缺血存活心肌节段总积分与HIF-1α、VEGF相关,检测血清HIF、VEGF可为指导冠心病介入治疗提供一个简单而实用的方法。
Objective To study the correlation between the expression of HIF-1α (HIF-1α) and vascular endothelial growth factor (VEGF) by using single photon emission computed tomography (SPECT) imaging.Methods The redistribution of 201Tl Like to determine the myocardial infarction patients with ischemic myocardial viability; ELISA and ELISA detection of HIF-1α and VEGF levels in patients with myocardial infarction and analyze the correlation between the expression of 201Tl myocardial ischemia and HIF-1α and VEGF.Results SPECT imaging detection The total score of surviving ischemic myocardium was significantly correlated with the changes of serum HIF-1α and VEGF levels (all P <0.001) .Conclusion The total score of ischemic surviving myocardium is related to HIF-1α and VEGF, Guiding coronary intervention provides a simple and practical method.