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癌症患儿如感染水痘,死亡率为7%。在急性成淋巴细胞白血病患儿中,水痘带状疱疹病毒(VZV)肺炎的发生率为32%,死亡率为25%。癌症患儿的肝炎、胰腺炎和血小板减少症也与严重的播散性水痘感染有关。因此,对免疫抑制的儿童早期预防水痘是非常有用的。本文旨在评价对无水痘史的癌症患儿,于化疗前给予水痘减毒活疫苗(LAVV)的安全性和预防作用。1985年7月～1987年2月对46例患有不同恶性肿瘤且无水痘史的儿童(男26例,女20例,年龄7月龄～11岁)进行了研究。其中32例皮下接种550噬斑形成单位(PFU)的LAVV
Children with cancer such as chickenpox infection, the mortality rate was 7%. In children with acute lymphoblastic leukemia, the incidence of varicella zoster virus (VZV) pneumonia was 32% with a mortality rate of 25%. Hepatitis, pancreatitis and thrombocytopenia in children with cancer are also associated with severe disseminated chickenpox infection. Therefore, early prevention of chickenpox in immunosuppressed children is very useful. This article aims to evaluate the safety and prophylaxis of pre-chemotherapy live attenuated varicella vaccine (LAVV) in children with cancer without chickenpox. From July 1985 to February 1987, 46 children (26 males and 20 females, aged 7 months to 11 years) with no history of varicella and different malignancies were studied. 32 of them were subcutaneously vaccinated with 550 plaque-forming units (PFU) of LAVV