《新刻注释马牛驼经大全集》(简称《大全集》)成书于1785年,是《元亨疗马集》的注释本,其中融汇了注释者郭怀西宝贵的临床经验。本文拟就该书对马五疗病的治疗,发掘其独到、供同道实践中参考。五疔是,《元亨疗马集》中记载的五种兽医外科疾病,此五疔为黑疗、筋疗、气疔、 “The Newly Engraved Commentary on the Bull Nimbus Collection” (abbreviated as “Daquan”) was completed in 1785. It is an annotated version of “Yuan Heng Ma Ma Ji”, which incorporates the valuable clinical experience of commentator Guo Huaixi. This article intends to explore the book’s treatment of the Five Healing Diseases and discover its uniqueness and reference in the practice of the same practitioner. Wuyi is the five kinds of veterinary surgical diseases recorded in “Yuan Heng Ma Ma Ji”. The Wuyi is called black therapy, gluten therapy, and gas stasis.