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研究葡萄糖对人THP-1单核分化巨噬细胞酰基辅酶A:胆固醇酰基转移酶1(ACAT-1)表达的影响。发现高糖作用下,巨噬细胞ACAT-1的mRNA及蛋白表达增加,这可能是糖尿病血管病变机制之
The effect of glucose on the expression of acyl-CoA: cholesterol acyltransferase 1 (ACAT-1) in human THP-1 monocyte-differentiated macrophages was studied. Found that high glucose, macrophage ACAT-1 mRNA and protein expression increased, which may be the mechanism of diabetic vascular disease