一、概述众所周知,雄激素通过和雄激素受体的结合来调控雄性的发育分化及维持正常的性功能。在雄激素受体的N端,也就是转录活性区域存在着多聚谷氨酰胺[(Gln)n]和多聚甘氨酸[(Gly)n]片段,两者分别由AR基因第一外显子中多态性微卫星序列(CAG)n和(GGC)n编码。(CAG)n重复序列在正 First, an overview As we all know, androgen and androgen receptor binding to regulate male development and differentiation and maintain normal sexual function. The polyglutamine [(Gln) n] and polyglycine [(Gly) n] fragments are present at the N-terminus of the androgen receptor, ie, transcriptionally active regions, both of which are represented by the first exon of the AR gene The polymorphic microsatellite sequences (CAG) n and (GGC) n codes. (CAG) n repeat sequence is positive