论文部分内容阅读
上皮性卵巢癌为最常见的卵巢癌，其起病隐匿、发展迅速且极易出现盆腹腔播散和腹膜后淋巴结转移，5年生存率极低。抗失巢凋亡是介导上皮性卵巢癌的发生和发展、转移、化疗耐药的关键因素。微 RNAs（miRNAs）在细胞的增殖和分化等多个生物过程中发挥重要作用，并且是肿瘤表观遗传学中主要机制之一。上皮性卵巢癌组织中出现相关 miRNAs 的异常表达，与卵巢癌发生进展、侵袭转移的关系密切。“,”Epithelial ovarian cancer is the most common type of ovarian cancer,with insidious onset, rapid development and is easy to disseminate to pelvic peritoneal and retroperitoneal lymph node,and its 5-year survival rate is extremely low.Anoikis suppression is a key factor to mediate the development,metasta-sis,chemotherapy resistance of epithelial ovarian carcinoma.MicroRNAs( miRNAs) play an crucial role in cell proliferation and differentiation in multiple biological processes,and is also one of the main mechanisms of epigenetics.Abnormal expression of miRNAs has appeared in epithelial ovarian cancer,meanwhile there is a close relationship with the progression,invasion and metastasis of ovarian cancer.