目的研究5-氟尿嘧啶间质化疗治疗胰腺癌的药代动力学特点。方法45名胰腺癌患者随机分为3组,分别给以间质化疗、介入化疗、全身化疗。结果间质化疗与全身化疗、介入化疗相比较,药物代谢的半衰期延长、表观分布容积增大,曲线下面积减小。结论间质化疗具有独特的药代动力学方面的优势,能够延长药物在局部的作用时间,提高局部的药物浓度。 Objective To study the pharmacokinetics of 5-fluorouracil-based interstitial chemotherapy in the treatment of pancreatic cancer. Methods 45 patients with pancreatic cancer were randomly divided into three groups, respectively, to the interstitial chemotherapy, interventional chemotherapy, systemic chemotherapy. Results Compared with chemotherapy and chemotherapy, interstitial chemotherapy prolonged the half-life of drug metabolism, the apparent volume of distribution increased and the area under the curve decreased. Conclusions Interstitial chemotherapy has unique pharmacokinetic advantages, which can prolong the acting time of the drug and improve the local drug concentration.