论文部分内容阅读
目的旨在研究慢性房颤患者心房肌瞬时外向钾通道电流的变化,为房颤机制的阐明提供更多的实验依据。方法心房肌标本取材于体外循环手术患者右心耳。采用全细胞膜片钳技术研究心房肌瞬时外向钾通道电流密度的变化。结果慢性心房颤动患者心房肌瞬时外向钾通道电流密度降低,在测试电位-20mV以上各电位水平时均有显著性差异(n=16,P<0.05)。结论慢性房颤时瞬时外向钾电流密度降低对房颤的电重构起一定的作用。
The aim of this study was to investigate the changes of transient outward potassium current in atrial myocardium of patients with chronic atrial fibrillation and to provide more experimental evidence for the elucidation of atrial fibrillation. Methods Atrial specimens were collected from the right atrial appendage of patients undergoing cardiopulmonary bypass surgery. The whole cell patch clamp technique was used to study the changes of the current density of transient outward potassium channel in atrial myocardium. Results The current density of transient outward potassium channel in atrial myocardium decreased in patients with chronic atrial fibrillation. There was a significant difference (n = 16, P <0.05) when the test potential was above -20mV. Conclusions Decreased transient outward potassium current in chronic atrial fibrillation may play a role in the electrical remodeling of atrial fibrillation.