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为了解幽门螺杆菌（Ｈｐ）感染与慢性胃病细胞凋亡的关系，我们采用原位末端标记法，对Ｈｐ阴性的３３例慢性胃炎和Ｈｐ阳性的３２例慢性胃炎、２９例胃溃疡、３０例胃癌的胃镜活检标本进行细胞凋亡检测。结果发现，凋亡指数分别为１．６％、１６．８％、２４．１％、６．３％，Ｈｐ阳性的胃病凋亡指数明显高于Ｈｐ阴性者（Ｐ＜０．０５～０．０１）。对３１例Ｈｐ阳性者进行根除治疗，其中２３例根除后细胞凋亡指数平均从１９．５％下降至５．８％，差异显著（Ｐ＜０．０５）；而８例根除失败者治疗前后凋亡指数无显著差异（Ｐ＞０．０５），提示Ｈｐ感染可促进细胞凋亡，根除Ｈｐ后可使细胞凋亡下降
In order to understand the relationship between Helicobacter pylori (Hp) infection and the apoptosis of chronic gastritis, we used the in situ end-labeling method to detect Hp negative in 33 chronic gastritis and Hp positive 32 chronic gastritis, 29 gastric ulcer, 30 Gastric cancer biopsy specimens for apoptosis detection. The apoptotic index was 1.6%, 16.8%, 24.1% and 6.3%, respectively. The apoptotic index of Hp positive gastric was significantly higher than that of Hp negative (P <0.05-0). 01). The eradication of 31 Hp-positive patients, of which 23 cases after eradication of apoptosis index averaged from 19.5% to 5.8%, the difference was significant (P <0.05); and 8 cases of eradication before and after treatment failure There was no significant difference in apoptotic index (P> 0.05), suggesting that Hp infection could promote apoptosis, and the apoptosis could be decreased after Hp eradication