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目的 分析41例血液透析后出血患者凝血酶及凝血因子,了解血液透析患者凝血机制和凝血因子的变化,分析出血原因.方法 抽取患者透析30 min后的血液各1.8 m L,分别注入109 mmol/L枸橼酸钠抗凝真空管和事先已加入10 g/L硫酸鱼精蛋白10 ul的枸橼酸钠抗凝管中,两管血浆同时测定凝血酶原时间(PT)、纤维蛋白原含量(Fg)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT).结果 加或不加10 g/L硫酸鱼精蛋白的凝血测定项目结果经过统计学处理有显著性的差别.结论 说明血液透析患者导致出血的原因,是透析过程中使用肝素过量. “,”Objective To analyze the haemorrhage after 41 cases of hemodialysis patients and thrombin clotting factors, understand the hemodialysis patients with the change of coagulation mechanism and blood coagulation factor, this paper analyzes the reasons of bleeding. Method To extract blood dialysis patients with 30 minutes each 1.8 mL, respectively, into the tendency for 109 / L sodium citrate anticoagulation vacuum tube and add 10 g/L prior protamine sulfate sodium citrate anticoagulation of 10 ul tube, the two tube plasma at the same time, the determination of prothrombin time (PT), fibrinogen (Fg), activate part clotting enzyme live time (APTT), thrombin time (TT). Results With or without 10 g/L of protamine sulfate coagulation determination project results have significant difference after statistics processing. Conclusion Shows that the causes of bleeding in patients receiving hemodialysis, excessive use of heparin is dialysis process.