前列腺特异性抗原 (PSA)是目前诊断前列腺癌的最重要的肿瘤标记物 ,二十多年来在前列腺癌的诊断、分期、预后判断和监测中的应用越来越广泛 ,但是它的敏感性和特异性还不是很高 ,一些提高PSA准确性的方法相继提出 ,并逐渐应用于临床。本文介绍了前列腺特异性抗原结构、功能和血清前列腺特异性抗原(PSA)的分子形式 ,并对目前的临床应用情况及提高PSA检测准确性的方法作一综述 Prostate specific antigen (PSA) is the most important tumor marker in the diagnosis of prostate cancer. For more than two decades, PSA has become more and more widely used in the diagnosis, staging, prognosis and monitoring of prostate cancer. However, its sensitivity And specificity is not very high, some methods to improve the accuracy of PSA have been put forward, and gradually applied to clinical. This article describes the prostate-specific antigen structure, function and serum prostate-specific antigen (PSA) molecular form, and the current clinical application and methods to improve the accuracy of PSA testing are reviewed